Example of a network-based approach for surveillance of occupational health exposures
The Occupational Exposome of the Non Hodgkin Lymphoma (NHL)
The concept of the occupational exposome is defined as a network of Occupational Health Problems (OHPs) sharing components of the occupational exposures, as a novel approach of considering OHP data in studies of the complex relationships between diseases and composite occupational exposures. An OHP is defined as a disease potentially related to work, associated to one to five hazards present in the occupational environment and an occupation potentially at the origin of the disease.
The nodes represent an OHP descibing a NHL observed in the RNV3P database and the links between the nodes represent at least one sharing occupational exposures (hazards or occupation). The white nodes are OHPs reported between 2002 and 2006, and the black ones were reported in 2007 denoted with the number of new observations.
The concept of the Occupational Exposome allows to characterize and to analyze the disease - exposure associations reported in the RNV3P database in the form of networks of relationships. As illustrated with the NHLs, the occupational exposome enables us to characterize the topology of similarities in exposure of OHPs in terms of networks with given properties, to identifying exposure groups (86 possible ones for the NHLs), and to study the complexity of the overlaps between groups in the overall structure of the network.